Selected References
Radnai L, Surman M, Hafenbreidel M, Young EJ, Stremel RF, Lin L, Bdiri B, Pasetto P, Jin X, Geedy M, Partridge JR, Patel A, Conlon M, Sellers JR, Cameron MD, Rumbaugh G, Griffin PR, Kamenecka TM, Miller CA. Discovery of Selective Inhibitors for In Vitroand In Vivo Interrogation of Skeletal Myosin II. ACS Chem Biol. 2021 Sep 24. doi: 10.1021/acschembio.1c00067.
Strutzenberg TS, Zhu Y, Novick SJ, Garcia-Ordonez RD, Doebelin C, He Y, Ra Chang M, Kamenecka TM, Edwards DP, Griffin PR. Conformational Changes of RORy During Response Element Recognition and Coregulator Engagement. J Mol Biol. 2021 Sep 18:167258. doi: 10.1016/j.jmb.2021.167258.
Zhang S, Ren Q, Novick SJ, Strutzenberg TS, Griffin PR, Bao H. One-step construction of circularized nanodiscs using SpyCatcher-SpyTag. Nat Commun. 2021 Sep 14;12(1):5451. doi: 10.1038/s41467-021-25737-7.
Min J, Nwachukwu JC, Min CK, Njeri JW, Srinivasan S, Rangarajan ES, Nettles CC, Sanabria Guillen V, Ziegler Y, Yan S, Carlson KE, Hou Y, Kim SH, Novick S, Pascal BD, Houtman R, Griffin PR, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. Dual-mechanism estrogen receptor inhibitors. Proc Natl Acad Sci U S A. 2021Aug 31;118(35):e2101657118. doi: 10.1073/pnas.2101657118.
Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K. Structure of an AMPK complex in an inactive, ATP-bound state. Science. 2021 Jul 23;373(6553):413-419. doi: 10.1126/science.abe7565; PMCID: PMC8428800.
Li K, Zheng J, Wirawan M, Trinh NM, Fedorova O, Griffin PR, Pyle AM, Luo D. Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) Nucleic Acids Res. 2021 Sep 27;49(17):9978-9991. doi: 10.1093/nar/gkab712; PMCID: PMC8464030.
Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD.Bioorg. Synthetic fluorescent MYC probe: Inhibitor binding site elucidation ad development of a high-throughput screening assay. Med Chem. 2021 Jul 15;42:116246. doi: 10.1016/j.bmc.2021.116246. Epub 2021 Jun 6; PMCID: PMC8279689.
Courouble VV, Dey SK, Yadav R, Timm J, Harrison JJEK, Ruiz FX, Arnold E, Griffin PR. Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Peoteomics. J Am Soc Mass Spectrom. 2021 Jul 7;32(7):1618-1630. doi: 10.1021/jasms.1c00086. Epub 2021 Jun 14; PMCID: PMC8231661.
Shin M, Watson ER, Song AS, Mindrebo JT, Novick SJ, Griffin PR, Wiseman RL, Lander GC. Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun. 2021 May 28;12(1):3239. PMCID: PMC8163871.
Sun L, Wei N, Kuhle B, Blocquel D, Novick S, Matuszek Z, Zhou H, He W, Zhang J, Weber T, Horvath R, Latour P, Pan T, Schimmel P, Griffin PR, Yang XL. CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2012898118. PMCID: PMC8020758.
Baroi S, Czernik PJ, Chougule A, Griffin PR, Lecka-Czernik B. PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss. Bone. 2021 Jun;147:115913. Epub 2021 Mar 16. PMCID: PMC8076091.
Courouble VV, Dey SK, Yadav R, Timm J, Harrison JJEK, Ruiz FX, Arnold E, Griffin PR. Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics. bioRxiv. 2021 Mar 6:2021.03.06.434214. Preprint. PMCID: PMC7941636.